Tinoridine hydrochloride
ethyl 2-amino-6-benzyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxylate monohydrochloride
CAS: 25913-34-2
Molecular Formula: C17H21ClN2O2S
Tinoridine hydrochloride - Names and Identifiers
Tinoridine hydrochloride - Physico-chemical Properties
| Molecular Formula | C17H21ClN2O2S |
| Molar Mass | 352.87884 |
| Melting Point | 234-235° (dec) |
| Storage Condition | Keep in dark place,Inert atmosphere,Room temperature |
| In vitro study | Tinoridine reduces a stable free radical, diphenyl-p-picrylhydrazyl, in the molar ratio of about 1:2, indicating its free radical scavenging ability. Tinoridine inhibits the lipid peroxidation in rat liver microsomes induced by xanthine-xanthine oxidase system in the presence of ADP and Fe 2+ , in which hydroxyl radical is formed. Tinoridine is demonstrated to be oxidized in the course of the lipid peroxidation by following the fluorescence derived from the oxidation product of tinoridine. It is also oxidized by the xanthine-xanthine oxidase system in the presence of Fe 2+ , but its oxidation is slow in the absence of Fe 2+ and almost completely inhibited by catalase. Tinoridine is also oxidized by H 2 O 2 -Fe 2+ system producing OH (Fenton reaction), but it does not affect the reduction of cytochrome c caused by superoxide radical. |
| In vivo study | CCl 4 aministration produces a marked decrease in the concentrations of liver microsomal cytochrome P-450 and G6Pase, indicating that hepatic endoplasmic reticulum function is disrupted. Prior treatment of the animals with tinoridine (100 mg/kg) significantly reduces the CCl 4 -induced alterations in the enzyme activities, and a rapid recovery toward the normal values is observed. |
Tinoridine hydrochloride - Risk and Safety
| Toxicity | LD50 orally in mice: 1601 mg/kg (Nakanishi, 1974) |
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View History
Tinoridine hydrochloride
O-甲胲
3-AMINO-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
3,5-二甲基-4-硝基吡啶氧化物
(1S,3R)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester
Human malignant melanoma cells
[5-(trifluoromethyl)thiophen-2-yl]methanamine hydrochloride
N-methoxycarbonyl-3-aminopyrazole-5-carboxylic acid ethyl ester
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-benzoate
2-Cyclohexen-1-one, 3-methyl-5-phenyl-, oxime
O-甲胲
3-AMINO-2-MERCAPTO-3H-QUINAZOLIN-4-ONE
3,5-二甲基-4-硝基吡啶氧化物
(1S,3R)-(3-Hydroxy-cyclohexyl)-carbamic acid tert-butyl ester
Human malignant melanoma cells
[5-(trifluoromethyl)thiophen-2-yl]methanamine hydrochloride
N-methoxycarbonyl-3-aminopyrazole-5-carboxylic acid ethyl ester
5'-O-[bis(4-methoxyphenyl)phenylmethyl]-P-(4-chlorophenyl)thymidylyl-(3'->5')-2'-deoxy-N-(2-methyl-1-oxopropyl)guanosine 3'-benzoate
2-Cyclohexen-1-one, 3-methyl-5-phenyl-, oxime